A recent peer-reviewed paper by Paul Shapiro, CEO of The Better Meat Co., and William Cumbelich, category analyst, explores the long history of Neurospora crassa in human food and its emerging role in modern plant-based meat alternatives.
Neurospora crassa, a filamentous fungus, has long been used in traditional fermented foods across Asia and Africa. While recent interest in this organism has surged within the alternative protein sector, it is by no means a new ingredient. Companies like The Better Meat Co. and Meati Foods are now harnessing N. crassa as a key component in the production of plant-based meat alternatives.
However, this fungus has deep cultural and nutritional roots that trace back centuries, particularly in foods like Indonesian oncom and Chinese okara. The challenge now lies in educating consumers about its long history of safe consumption and addressing potential concerns around its classification as a type of mold.
N. crassa’s role in alt protein
In the growing alternative protein industry, companies such as The Better Meat Co. and Meati Foods are using N. crassa to produce mycoprotein, a key ingredient in their plant-based products. Unlike traditional methods of growing fungi like Fusarium venenatum (used in Quorn products), these companies focus on cultivating N. crassa’s whole biomass in fermentation systems designed to create a high-protein, meat-like texture.
The fungus’s natural ability to convert plant byproducts into nutrient-dense food has garnered attention from food technology companies looking to meet the increasing demand for sustainable, animal-free protein sources.
The Better Meat Co., for instance, has already received “generally recognized as safe” (GRAS) status for N. crassa from the U.S. Food and Drug Administration and similar approval in Singapore. While these regulatory advancements have opened the door for wider use of N. crassa in food, the public is still grappling with the perception of its safety and its place in the modern food system. N. crassa, as a type of mold, has stirred some concerns, especially given that many people associate molds with negative health effects. However, the reality is that humans have been consuming this incredible organism for centuries through fermented foods like oncom and okara.
Educating the consumer and overcoming perception challenges
Despite its proven safety and historical use, N. crassa’s classification as a “mold” often leads to confusion and skepticism. As a result, companies in the alternative protein space are tasked with educating the public about the safety, nutritional benefits, and long history of N. crassa in food. The case of Meati Foods provides an example of the challenges in consumer perception. Initially, Meati marketed its products as being made from “mushroom root,” a term that inaccurately described the source of its mycoprotein. The company later faced legal action over this misleading claim, as their products were actually derived from N. crassa, not mushrooms.
This lawsuit showcases the fine line that plant-based companies walk when it comes to marketing ingredients that consumers may not be familiar with. It’s crucial to educate consumers that this fungus has been a safe and integral part of traditional diets in several cultures for centuries. In Indonesia, for example, oncom, a fermented food made from peanut presscake or soybean dregs, has long been produced using N. crassa. Similarly, in China, fermented okara has been a staple, enriched by the nutritional benefits of N. crassa.

The nutritional benefits of N. crassa
The appeal of N. crassa as an alternative protein source lies in its nutritional profile. It offers a complete protein, containing all nine essential amino acids, and is rich in micronutrients such as B vitamins, iron, and zinc. This makes it an attractive option for plant-based meat companies aiming to replicate the nutritional content of animal-derived meats.
Moreover, N. crassa is high in fiber, especially soluble fiber, which can support digestive health. Its fermentation process also enhances the bioavailability of key minerals, which are often difficult for the human body to absorb from plant-based sources alone.
Beyond its protein content, the fermentation process involving N. crassa also contributes to food safety. Unlike some other fungi, which can produce harmful mycotoxins, N. crassa has been shown to reduce the presence of aflatoxins in fermented foods, making it a safer choice for large-scale food production. This safety profile, along with its ability to transform plant byproducts into nutritious food, makes N. crassa an ideal ingredient for companies looking to meet the demands of a growing population while addressing the environmental concerns tied to animal agriculture.

Bridging tradition and innovation
The rising interest in N. crassa as an ingredient in plant-based meat products is an example of how traditional food practices are converging with modern food technology. While fermentation with N. crassa has been a staple in cultures like Indonesia and China for centuries, the commercial application of this fungus in alternative meat production represents a new chapter in its long history.
Companies leveraging N. crassa are not just tapping into its nutritional value but also its potential to reduce the environmental impact of food production. The cultivation of N. crassa for food is far more resource-efficient than raising animals for meat, making it an attractive alternative for a more sustainable food system.
The challenge now lies in ensuring that consumers recognize N. crassa for what it truly is: a safe, sustainable, and nutritionally beneficial food ingredient with a centuries-old legacy. With further education and increased transparency, N. crassa could gain broader acceptance in the alternative protein market.